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1.
1. a pansexual person; one who would consider a sexual and/or emotional relationship with male, female, or transgender
2. A girl who likes anal and vaginal sex; a boy who likes to recieve anal, as well as give penile intercourse
Kelly likes it in the front and the back, she's ambisextrious.

I am not straight, I am ambisextrious.
by Scarlett June 13, 2003
 
2.
A person who partakes in sexual activities with either sex.
"Damn! Your girl is chowing box over there."
"Yeah, she's ambisextrious."
"Nice."
by G is for gangsta February 23, 2008