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5.
(def 1) On top of, either in a literal or metaphorical sense.

(def 2) Pursuing or showing interest in.

(def 3) Imminent or present.

Cultural note: This phrase has received some popularity due to it's occasional use by the character Strong Bad on the Homestar Runner website.
(def 1) George had three puppies, and every time he sat down to watch TV they were all up on his lap.

(def 2) Commercials would have us believe that a guy just has to use the right brand of deodorant and the ladies will be all up ons him.

(def 3) So it's finally Halloween and the Autumn months are all upon us.
by Peter K. September 04, 2007
 
1.
The state of flirting with a man, especially one who has used the ab-abber. See Homestar Runner.
"The ladies will be all up ons."
by KaiserMonkey August 21, 2003
 
2.
the level of sexual intent shown to a member of the opposite sex, see www.homestarrunner.com
"Rich got a jeep and the bitches were all up ons"
by elvis February 20, 2005
 
3.
Used to mean an encroachment of personal privacy or space, invited or uninvited. Some form of pressure, either physical or mental, i.e. a woman dancing really close to another guy; a landlord pressuring for rent.

Can be used to imply sexual interest, as in someone who is intensely flirting/mackin on someone else, either physically or figuratively. Implies intense or clear sexual interest and pursuit. Same as all over him, related to all up on his balls or all up in his business. Can be used for both genders (i.e. he was all up on her)
Girl was all up on him in the club, backin her booty up.

She was all up on him, wouldn't leave him alone, tryin to get his number n shit

Damn, why you all up on me? I'll get you your shit, I swear.
by ptree March 25, 2008
 
4.
"All up ons" is a colloquial usage describing popularity. "It means they really like you". It can also mean something is on, around or close to someone.
"Well played, Strong Bad. Those ladies are sure to be all up ons."
by Gary D. August 18, 2007
 
6.
adj. Condensed "all up ons", ascribed to a person who is shamelessly flirting with someone else, especially when the flirter is blatantly disregarding flirtee's need for personal space; being all up in the grill of the flirtee.
speaker 1: Did you see Brandon last night? He was allupons my shit!

spearker 2: Dude, I know. It must have been that hot shirt you were wearing.
by Furious May 01, 2005
 
7.
when one person is sexually attracted to another person.
I was wearing my Autobot T-shirt and the ladies were all up ons!

I wish I was Sugar shum! That would make her all up ons!
by AlfaTrion August 20, 2003