Top Definition
Abbreviation for the words, "You Should Shut Up" This abbreviation should be put in placed after "YOLO" to show a distaste for the phrase "You Only Live Once" this can be for various reasons, for example, you hate YOLO because its not like you live twice or simply because it sounds weird.
Person 1"Let's get mortal tonight YOLO!"
Person 2"YOLO? YSSU"
by negativella July 30, 2012

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