This is an abbreviation for: "You Suck At Life"
Hey Dexter! YSAL! You (really) Suck At Life! And you smell like poo too!
by Humpty Dizzle February 02, 2006
1 more definition
Acronym for "You Suck At Life" which is an offensive comment that can be used in almost any negative context but most often used as a replacement for calling someone a loser.
You got dumped again?!? YSAL man.
by Funmunke July 12, 2013