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1.
1) A mixed shot, containing a ground up Vicodin and a shot of vodka. Acceptable to substitute the vodka with any other liquor, while still being defined as a vicoshot.

2) Quite possibly the most dangerous thing I've ever invented.
What happened last night? I pounded so many vicoshots I blacked out, puked all over my my girlfriend, woke up with no pants or shirt, and shit myself.
by G-Stoned April 15, 2011