Top Definition
The negative physical and mental effects you feel when you return to work or school after an extended vacation. Generally these include tiredness, confusion, and a headache, amongst others.
Jim: "Hey Ron, you look pretty stressed out, what's wrong?"
Ron: "The three week Christmas break has given me Vacation withdrawals."
Jim: "Aw, that blows."
by StalterMan February 13, 2010

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