Top Definition
When you put your penis in a man's anus for the first time.

A TRUE Up In Adam would be having a sexual encounter with a man for the first time, then putting your penis in his anus.
I've always wanted to have sex with another man, so I finally went Up In Adam last Friday.

I've had sex with many girls before, but I want to go Up In Adam this weekend.
by ExpertEntrepreneur August 03, 2011
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