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When two or more things are unrelated. when the gramatical layout of the sentence doesn't allow for the word "unrelated" the word "unrelation" can take it's place
John: This pic is getting some really unrelated arguments, "kinkyness and frozen bread" all on a pic of gemma with a leather jacket on.

Smith: unrelation ftw?
by p3rs0n42 March 08, 2009