UwO can be used in multiple ways

1. You can use UwO to assert dominance

2. Can also be a way to show that something or someone is too cute

3. It Can be used when your speechless
Scenario 1. Sally: omg a doggy UWO

Samantha: UWO

Scenario2. sally: that’s stupid Samantha

Samantha: UWO!

sally: S-Sorry!
by God of UwO April 6, 2019
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Finally, after years of gamers and furries not telling me, I just realized what UwU and OwO means! UwU is eyes closed, and OwO is eyes open. Is that what it's supposed to mean??? Well if it is then I guess UwO is a winky face. I still don't get why someone wouldn't just use something else, but OK.
Furry 1: UwU
Furry 2: OwO
Random Person UwO ;-)
Everyone Else: ????
by an idiot defines... May 11, 2020
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it so when a furry can't decide if they want to be an uwu or an owo furry
by UwO furry September 23, 2019
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When an UwU or OwO just isn't enough.
by KittyCait October 4, 2020
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This word is meaning the two: owo , uwu meaing winking in a lustful or cute way
Tracey: Wow you got a boyfriend
Sasha: yup uwo *
by Supimabeyourbro March 26, 2019
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The University of Western Ontario (UWO) is largely made up of intelligent and attractive academics, and as such, is the target of jealous ranting from those who are not so well endowed. These spastic complainers often attend other schools in Ontario and were either not accepted to UWO, or chose not to apply as they would stand out as slavering ghouls on the UWO campus.
UWO applicant: Have you submitted your application to UWO yet?

Other Ontario University applicant: insert spazzy whining here
by Wayne2001 November 4, 2010
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