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1. UPI
Un-Identified Party Injury, Mysterious injuries discovered after a a period of intoxication.
This morning, I woke up with a UPI on my leg.
by McBain Feb 7, 2002 add a video
2. upi
a word used in instant messaging when you accidently have your right hand fingers off by one on the home row on a qwerty keyboard.
you're

becomes

upi
re
3. Upi
An indian girl who moved to the u.s.
She thinks she is ugly but in reality she is very pretty.
She likes wanna-be gangstaas and black people and likes it when people mistake her for mexican c;
Black Man- Yo dawg, who is that mexican girl?
White Man- You mean Upi? She's not mexican...shes indian
Black Man- Ahh...well she's hot
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