A combination of twit (an insignificant, bothersome person) and glitterati (social elites). The twitterati is a group of gay men that are not important, but think they are. Members of the twitterati are usually pretentious and preppy, well-groomed and snotty. Depending on where you live and what social class they are trying to attain, members of the twitterati will either bore you with the latest news on Paris Hilton and Britney Spears or go on and on about their up-and-coming career in opera or their plans to have a penthouse in Manhattan.
Can be used collectively, or to address individual members within a twitterati group as a whole.
Those idiots think they got class, but really they are just some fugly little twitterati.