A person who uses Twitter way too much, think it's the best thing in the world and fills up your queue with crap. They tweet about what they're eating, when they take a shit, and other banal, boring and otherwise vapid drivel.
Jesus fucking Christy! I've gotten 20 tweets today from Bob about his shoes! What a Tweethole.
by PoopyMcGee April 09, 2009
1 more definition
Courtney Love's big tweet hole cost her big bucks. Kanye West can't keep his tweet hole shut. Kim Kardashian's getting paid every time she opens her tweet hole.
by AdonisGenes March 04, 2011