Tweetums refers to a woman/girl who's acting childish/babylike in order to be seen as cute - often times failing in the matter especially when you're a whale-sized female who looks like she spawned 10 kids already.
It is a sweet endearment with a babylike twist. (Babytalk) Sometimes the batting of eyelashes is included.
Tweetums appears to be nauseatingly cute/insipid.
Tweetums is often used in Filipino context. Commonly, people who are seen to be "tweetums" can and may be pretentious, clingy, attention whores, and just plainly those who think they're cute but they're really not.
Pa-tweetums ka pa, ate! Alamnaman namin na laspag ka na!
A gathering of nerds attempting social contact, likely for the first time. Usually disintegrates into everyone running to the nearest computer to type to one another.
Tommy: Hey Jethro, quit playing WoW its time to meet some folks at the tweetup!
Jethro: Oh yeah I forgotabout that, I can't wait to meet BigBootay421 at the tweetup, but first I need to slay this orc!