peaking on LSD and tweaking on methamphetamine simultaneously. Being under the influence of speed and acid at the same time.
by Bill B. June 24, 2005
Don: aye, Ern over there actin a fool
Boat: yea I know! what the hell is he doin?
Don: Foenem Tweakin’ for real brother
Boat: yea I know! what the hell is he doin?
Don: Foenem Tweakin’ for real brother
by Blakernator January 25, 2020
From Bobby Shmurdas "Hot Nigga". Tweaking is a movement where you move your knees back and forth and you move your hands to your chest back and forth.
"and now we tweakin hoe"
by Sappy Panda November 6, 2014
by Kate van Awesomeness November 19, 2016
a meth head or crack head also know as a tweaker that stands on the roof and trys to land airplane's/UFOs
by tweakin-beakin July 1, 2019
Omg call Karon, she’s driving down the gravel road with her tweakin beacon on again. That bright headlamp is a sure way to catch a case at 3a.m.
by Randyom15 May 10, 2021
It basically means you're off the shits, your under the influence of something, for example, Molly, or anything in that range
by Sillygoose420 March 7, 2016