Currently the Fifth Hokage (also known as Godaime) of Konoha from the Japanese manga/anime series Naruto. Together with Orochimaru and Jiraiya, Tsunade makes up the famed trio known as the Legendary Sannin. She has enormous strength, a trait she gained through her exceptional chakra control.

The granddaughter of the 1st Hokage of Konoha (founder of the hidden village itself), she is well-respected and most likely belongs to a noble clan. She lost her younger brother and lover during the war and that subsequently causes her to develop hemophobia. Tsunade manages to overcome the fear during her confrontation with Orochimaru, right before she accepts the position of Hokage.

She owns a priceless crystal necklace, an heirloom from the 1st Hokage. It is believed that the bearer of the necklace, other than Tsunade, will die. However, Naruto

One of the legendary Sannins with massive knockers. She is blonde and is now currently the 5th hokage of Konoha, Sakura is now her current apprentice.
She ahs inhumane strength and once knocked Jiraiya 100 metres back.

When you style your pigtails so the back of your head looks like a pair of tits. Derived from the Naruto character Tsunade, who actually styles her pigtails in such a way.