When you've passed the point of tanger and have moved onto a killing rage. This is usually brought on by being angry due to lack of sleep, and encountering one or several insufferable individuals. Since there seems to be no shortage of insufferable individuals, one can only assume a lot of people are tangry, if not tihomicidal.
I was wallowing in tanger when Joe asked me if my panties were in a bunch. I then commited tihomicide.