A syndrome when a male has an ass so so fat it gets them to a state where he shows insecurity, upset, annoyed, angry, and quiet
Friend A: Aye bro do you struggle to find pants?
Friend B: Bro stop asking me that your chatting, your pissing me off!

Friend: (That’s that thick booty nigga syndrome...)
by Devon Davis June 8, 2021
Get the Thick booty Nigga syndrome mug.