When a song has an awesome build up to the drop and then ruins it all when the drop actually happens.
*listening to music that's about to hit the drop*

Guy1: "Holy shit this song is freaking amazing!"
Guy2: "I cannot wait to see what happens after the drop."

*Song ruins itself with shitty music after the drop*

Guy1: "Dafuq is this?"
Guy2: "This song has The Drop Syndrome. :( "
by viper Infinity September 7, 2014
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A medical condition mostly prominent in the elderly community in which a large flatulence is expelled so violently the victim loses their footing and fall over as a side effect.
They lady who fell over at the line in Luby's to first responders that she has Hindermen's Drop Syndrome as a pre-existing condition.
by Dick Whispers222 July 28, 2011
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The negative sensation one encounters upon discovering their Facebook friend numbers dropping.
Another one? Friend Drop Syndrome.
by JoeNJ2 October 27, 2011
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When the second drop in a dubstep/trap song doesn't come anywhere close to the first
Man, that new skrillex song has an awful case of second drop syndrome.
by Noxington March 4, 2015
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