That's a negative Ghost Rider 

The saying originated in the movie top gun, when Maverick requests a fly-by, and is denied by the commanding officer.

It was later quoted by David Spade in a 7-up commercial, and has also been used in a few other less reputable media segments.

Basically, it just means no. The phrase Ghost Rider eludes to the pilot's alias, and is an illusion to the comic book character Ghost Rider (though I don't think that is significant).

Can I have pickles on that sub?

That's a negative Ghost Rider.

That's a negative Ghost Rider by 4n0nym0u5! March 25, 2011

That's a negative, Ghostrider. 

Everyone else says it's from Top Gun or whatever. But, yeah, no. IT'S FROM THE 7UP COMMERCIAL WITH DAVID SPADE.

It's a hipster way of saying NOOO.

Neighbor: Am I allowed to swim in your pool?

David Spade: That's a negative, ghostrider.

That's a negative, Ghostrider. by Jayma Mays January 23, 2011