"Tktk" is an offensive and derogatory response used with the intent of the recipient to not recognize it as an insult. Like flicking off an infant, or cheerfully cussing someone out in a language they don't understand.
Guy:"Dude, that jacket totally makes you look like Justin Bieber."
Dude:"Tktk."
Guy:"...?"
by Narutofan67 January 13, 2011

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