A short one word abbreviation for "turns me on". An expression meant to show that something someone said, or something you see turns you on; gets you hot and horny, interests you, or that you simply agree with the latter statement.
Man A: There's no way she's our waitress, she's way too fine.
Man B: TISMO
Nerd A: Last night i raided the shit out of Derkish Hallows and got like 5 different Power Axes!
Nerd B: TISMO
Woman A: Look at that guy, i'd totally sleep with him!
Woman B: TISMO
Tourist A: Macho Picho is by far the most beautiful place i've ever been to...
Tourist B: TISMO