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1.
The Upper Peninsula of Michigan. Quite rugged and attractive to real outdoorsmen.
I got that deer in THE U P last winter.
by Cool Rich April 03, 2007
 
2.
The condition of someone looking like they are mentally retarded but being a fully functional without any serious mental deficiencies.

Can also be known as "Ups Syndrome."
Damn that short dude from American Pickers looks like he has The Ups.

I thought that Jimmy Clausen had down syndrome, but it turns out he just has The Ups
by Number Jonny 5 September 23, 2010
 
3.
THE up, as in not just "What's up" but "What is THE up," specifying a specific major event.
"Yo dawg, what is the up?"
by SamT June 09, 2005