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1.
The couple Spike, a vampire, and Buffy, the slayer, from the Buffy The Vampire Slayer series. Spike fell in love with Buffy and got his soul back for her. Spuffy is the couple with the most unique storyline, best chemistry, and hottest sex scenes.
Spuffy is the best couple ever to appear on TV!
by Jessgurl June 21, 2005
 
2.
Term coined to describe the love/hate relationship between "Spike" and "Buffy", two characters played by James Marsters and Sarah Michelle Gellar in the hit series "Buffy The Vampire Slayer".

It is typically used as an adjective in normal conversation to exemplify traits exhibited in their on-screen relationship.
"Our relationship was very spuffy."
by Darren Coleman October 13, 2003
 
3.
The combined names "Buffy" and "Spike," as seen on Buffy: The Vampire Slayer.

Normally used to describe a fanfiction written about their relationship.
I just read this great spuffy piece.
by iamgoose2 July 30, 2004
 
4.
Used when referring to the couple Spike and Buffy from Buffy the Vampire Slayer
Spuffy scenes are the best.
by Alexa October 12, 2004
 
5.
n. The momentary full body muscular contraction immediately following the action of an early morning bladder release or the act of yawning.
No I'm not seizing. That was just a spuffy.
by PlatinumLuthier September 14, 2011
 
6.
Spiffier than spiffy; spiffy, but in a very plush way.
That sectional is spuffy, oversized and extra-deep, you could spend the entire weekend on it.
by deusdiabolus November 14, 2009
 
7.
Spuffy is a common name given to pet raccoons due to their propensity for constant masturbation.
John D "Dude...did you here that Ben got a pet raccoon?! He called it Spuffy"
John G "Ahhh! That explains the stains on the walls"
by Cpt Brownsauce Sandwich December 15, 2009