The couple Spike, a vampire, and Buffy, the slayer, from the Buffy The Vampire Slayer series. Spike fell in love with Buffy and got his soul back for her. Spuffy is the couple with the most unique storyline, best chemistry, and hottest sex scenes.
Spuffy is the best couple ever to appear on TV!
by Jessgurl July 3, 2005
Get the Spuffymug. A relationship, or ship, name for the couple Spike and Buffy from the TV show Buffy the Vampire Slayer (BTVS) that originally aired in 1997.
Spuffy is so cute; I ship them!
by toospiffy4you May 25, 2015
Get the Spuffymug. by Alexa October 12, 2004
Get the Spuffymug. John D "Dude...did you here that Ben got a pet raccoon?! He called it Spuffy"
John G "Ahhh! That explains the stains on the walls"
John G "Ahhh! That explains the stains on the walls"
by Cpt Brownsauce Sandwich December 15, 2009
Get the Spuffymug. n. The momentary full body muscular contraction immediately following the action of an early morning bladder release or the act of yawning.
by PlatinumLuthier September 15, 2011
Get the Spuffymug. The combined names "Buffy" and "Spike," as seen on Buffy: The Vampire Slayer.
Normally used to describe a fanfiction written about their relationship.
Normally used to describe a fanfiction written about their relationship.
by iamgoose2 July 30, 2004
Get the spuffymug. Term coined to describe the love/hate relationship between "Spike" and "Buffy", two characters played by James Marsters and Sarah Michelle Gellar in the hit series "Buffy The Vampire Slayer".
It is typically used as an adjective in normal conversation to exemplify traits exhibited in their on-screen relationship.
It is typically used as an adjective in normal conversation to exemplify traits exhibited in their on-screen relationship.
"Our relationship was very spuffy."
by Darren Coleman October 13, 2003
Get the spuffymug.