Top Definition
To fuck a bitch without caring about her.
The opposite of slaying hole would be making love.
Example 1

Rob : "you see that bitch?"
Phil: "yeah shes fucking hot"
Rob : "I slayed that hole last night bro"
Phil: "wow"

Example 2

Bob : "omg I wanna slay hole right now."

Example 3

Tyrone : "Ay shawty let me slay that!"
Laquisha : "In yo dreams"
by TheForkinator December 22, 2008
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