Single Mom-itis Share definition Flag Stressed out mom. Mom in dire need of a visit from the cleaning fairy. A mom that needs a night out on the town. She had Single Mom-itis so bad she thought she was going nuts. Single Mom-itis by LittleTLC October 10, 2011 0 0 Get merch Get the Single Mom-itis mug. Buy Now — $32.95 See more merch