There is no worded, or formal, definition of Sikeston, MO, really.
It is only defined by use of examples.
Also, certain things can only be described accurately by using this term.
Therefore, the definition of Sikeston, MO is the phrase itself.
"Man that girl is ugly."
"Yeah she is sikeston, MO fo sho."
"I heard that she is really shady."
"Yeah, that's sikeston."
by Todd July 8, 2003
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A shit place in Sikeston. Literally gross.
Have you been to Sikeston? Just looking at it was gross.
by MoonHippie420 June 10, 2021
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