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Taken from the hit sitcom "Family Guy," this phrase can be said to anybody who either kills a joke, makes an uncalled for comment, or otherwise just needs to be ridiculed spontaneously.
Steve: "I think that octoberfest might be the best beer ever."

Bobby: "I agree"

Jeff: "I think beer is disgusting no matter what it is."

Steve to Jeff: "Shut up, Meg."
by whitey McRosenski September 17, 2010