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1.
From Yiddish origin. A clumsy, inept, or foolish person.
As quoted from the film Independence Day:

"If I knew I was going to meet the President I would have wore a tie. I mean look at me, I look like a shlemiel."
by Mata99 May 30, 2009
 
2.
A sad sack, a loser, a poor slob; from the Yiddish and German. "A shlemiel drops it; a shlemazel picks it up."

He made a living playing a shlemiel on TV.
by cornholio October 04, 2003
 
3.
From Yiddish Orgin, which is a semetic language, meaning fool.
Your buring the popcorn you shlemiel!
by Ben Leventer January 26, 2006