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1.
When you're screwed over (or boned) in the worse possible manner.
When the hull of an intergalactic vessel breaks and you're stuck in a vacuum of space because of it.

Zach Hammond: Be careful, the whole section leads into the vacuum of space......and the Necromorphs have completely taken over the ship!

Isaac Clarke: Oh shittery fuck fuck!
by Meta Tam When Hi Non July 27, 2010
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