When the results of a prank, or act in general, take a negative spin leaving the prankster in a shitload of trouble.
Barry: (throws rock and breaks window) SHIT! (and runs)
William: He totally pulled a "shit and run."
by Lola Drift. October 26, 2008
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When someone farts and leaves the room for you all to suffer their stench
Alex:(fart)

Jim:what the hell!

Alex:(runs and closes door)

Jim: don't just shit-n-run!
by Alsk April 7, 2015
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When a friend or relative arrives at one's place of residence for the sole purpose of dropping a deuce and leaving.
My brother frequently pulls a shit 'n' run at my house during his lunch break.
by darkkterror February 27, 2007
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When Somebody takes a shit in your bathroom and gets it everywhere and then leaves right after
Trevor: theres Shit everywhere Johnny: looks like it was a shit n run
by cryo30 October 1, 2010
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when someone is shooting at you or your girlfriend has pms. either way your pretty much totally fucked.
guy with a gun, or your girl friend at one time of the month, as in oh shit! fucking run!
by Im totally hyper October 18, 2007
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ringing somebodys doorbell, taking a ginormous dump on the step and running for your life whilst doing evil laughs ...
Bobby: What do you want to do tonight?
Jimmy: lets shit & run at marias house
Bobby: lets do it

later maria opens her door

Maria: ahhhh what the fuck is this thing ahhhhhh ... mmm tastes good...
by Abi and Katie July 4, 2008
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When you've held in a shit so long that you have to run to the bathroom and barely make it on the toilet.
May or may not involve bad cases of diarrhea.
"OMGG!! Get out da way!! I'M SHIT RUNIN'!!!!"

"Dude, my mom got mad at me when I shit ran to the bathroom while we were having 'serious discussion'."

"Oh damn, I think I'm gonna have to shit run soon!"
by -lexiie December 3, 2009
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