Top Definition
1. One who is extremely Attractive;Handsome
2. Sexual position impossible to describe in words.
"Dude... I totally Santilloed her last night!"
"YOU WHAT!!??!!!??"

"whoa!, she's really Santillo!"

by K Fez January 13, 2008
a person that never gets laid. a person known for striking out on all levels.
my friend pulled a santillo and went home alone again
by Dark Danny Brown February 13, 2007
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