look up any word, like dirty sanchez:
 
1.
to walk or run while masturbating, usually to avoid disgusted looks
I was downstairs, about to get off when my parents pull in the garage, so I have to run and gun all the way upstairs before i can finish
by Dalmondo Jones September 15, 2008
 
2.
It's a literal device, you just run away while shooting something... confusing ain't it?
Dude, try to run and gun when the friggen San An Army is after you!
by Tokeyo Beat April 30, 2008