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1.
A second night of drinking and getting drunk.
"After last night, I'm ready for round two!"
by heyyitsblondie July 04, 2009
 
2.
A phrase used to signify a secondary round of bowel movements; usually occuring withing 3-5 minutes of wiping, flushing, and washing the hands.
Danny had just closed the bathroom door when his stomach rumbled again, causing him to turn around and say "uh-oh, round two..."
by mr. 123 February 03, 2010