Powder my nose 

Running to the bathroom for a quick snort of cocaine.

Mary: "Jen, I'm going to go powder my nose. Wanna come with'?
Jennifer: "Why do you have a straw for?"
Mary: To snort some of this awesome blow I just scored."

Powder my nose by K4t333 January 25, 2011

Powder my nose 

A sarcastic euphemism for going to drop a deuce, have a private conversation, or simply jet from a situation (typically a table).

(At a restaurant)
Man on date: The dividends on my Facebook stock payed my dues for the swingers club this year.
Woman on date: Excuse me, I'm going to go powder my nose.

Powder my nose by RobDestiny April 10, 2017

Powder my nose 

Go to bathroom and snort drugs

Am going to go to the bathroom and powder my nose - Mia Wallace, Pulp Fiction

Powder my nose by V Chen November 23, 2016