1. When the real world hits you like a slap to the face after a fierce masturbation session.
Joe: "I beat off with birthday cake frosting... I hated myself and wanted to die..."

Terry: " Sounds like Post Masturbation Depression Syndrome to me. Don't sweat it, bro. It's normal. But that IS fucked up..."
by mbarfiel February 5, 2010
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PMDS is a very serious illness that both men and woman can suffer throughout their lives. It is after the art of masturbation in which you will feel sad and depressed at yourself and your life. (This is a very serious illness and must be taken with extreme caution given the effects it can have on any given individual)
Jimmy: I just masturbated and I feel a deep sadness feeling inside of me.
Doctor: Well Jimmy it seems to me that you might have PMDS (Post Masturbation Depression Syndrome)
Jimmy: What does that mean doctor
Doctor: Whenever you pleasure yourself through the art of masturbation, you will become ill with depression after you ejaculate.
by Ian’s mom August 14, 2018
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