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1.
When you sneeze, cough, fart, and pee on yourself a little, all at the same time.
"Aahhchoo!$&@$%^#£!... Oops"

God bless you! Did you just pickleweezle?!
by Bomechelle December 18, 2013
 
2.
Insult, dumbass or jackass
WOW! that guy is such a pickle-weezle
by zeus May 24, 2004