Top Definition
A condition that affects 1 in 20 college students in which no matter how much older they get, they will always be a freshman.
Student 1: I talked to that senior Dave.

Student 2: Dave? He's a freshman dude.

Student 1: Isn't he 21?

Student 2: Yeah but he has PFS, also known as Perpetual Freshman Syndrome. He'll always be a freshman.
by Rytic June 15, 2013

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