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1.
A person or place that is beat down or worn out. Someone who is hung over or lacking rest. It can also describe someone getting drunk or partying really hard. It can be said in plural or singular form, both have equal meanings.
"I'm so Permed from last nights drinks I can barely function at work today" "Tonight I'm gonna get my Perm on!" "May the Perm be with you" "Was she cute? Or was she Perm" "
by Drunklando October 12, 2011
 
2.
Permed is short for permanent ownage. Usually used in the game Counter-Strike when someone who is leet headshots a nub and they leave the server and never play the game again. Could be considered the highest level of pwnage (see pwn)
(in game)

*nub dies*
nub says: OMG J00 SUCK
*unnamed has left the game*
white lighter says: holy crap, that nub got permed
by White Lighter July 27, 2005