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permafuck 

An adjective that means you do so many drugs that your brain is permanently fried. You forget how to do easy things, like remember to go to class or put your car in park.
Dude A: Hey dude did you see Cody at lunch today?

Dude B: Yeah dude he's been there for three hours and just got detention for skipping class. He's totally permafucked.
permafuck by poolmaster41 April 21, 2009

pentafucked 

When you "roast" the douchebag at the party multiple times; fucking the party pooper's shit up; wrecking his shit so much he doesn't even know it's happening.
I spit in his drink 5 times I pentafucked the shit out of that douchebag
pentafucked by Mightbecrazy November 20, 2014

permafuck 

To be in or produce a permanent state of contextual existance in which parties involved are completely and utterly fucked, with no conceivable reprieve and from which there is no escape. See also FUBAR
Guy 1: So how'd your GF know you were cheating? You get ratted out?
Guy 2: No she's got a videotape.
Guy 1: Dude, you're permafucked.

A gangmember rapes a hooker in an alley. Little does he know that the hooker has AIDS. Now he's facing charges of sexual assault, the pimp wants revenge and on top of it all he's gonna die from AIDS in a couple of years. You don't get more permafucked than that.
permafuck by Lord CrutchCricket December 9, 2008
An truncated version of the phrase "perfectly fucked", similiar to fubar, and snafu perfucked is a situational modifier used to describe an event that ends in catastrophe, or disaster.
"At the time eating eight cupcakes in a row seemed like a good idea, but soon Wade's stomach became perfucked"
perfucked by Alex Makaryk November 7, 2007

Perma-Fucked 

The state of being permanently altering your future or your body negatively, due to injury or a retarded decision.
I cut the nerves and tendons in my finger and now it's perma-fucked. I knocked a random girl up after a one night stand and now I'm Perma-fucked

permafuck 

The name of the novel that was featured on the show Weeds. It was written by Andy's crazy ex-girlfriend from Alaska. "Permafuck: A Journal of Spirit Rape"
We are in serious trouble.

I know. We're permafucked.
permafuck by Mark Fredericksen January 13, 2008