To be in or produce a permanent
state of contextual existance in which parties involved are completely and utterly fucked, with no conceivable reprieve and from which there is no
escape. See also
FUBAR
Guy 1: So how'd your GF know you were cheating? You get ratted out?
Guy 2: No she's got a videotape.
Guy 1: Dude, you're permafucked.
A gangmember rapes a hooker in an alley. Little does he know that the hooker has
AIDS. Now he's facing charges of sexual assault, the
pimp wants revenge and on top of it all he's gonna die from
AIDS in a couple of years. You don't get more permafucked than that.