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1.
1. Usually used in MOORPG's to describe an event where a high level NPC or monster kills your 10,000 hit point character in one fatal swoop.

2. Can also be used to describe an event where serious pwnage is credited.

1.My decked out Pally got One Shotted by Onyxia.

2.The snowboarding spill was so epic that dude got One Shotted to the top.
by Imallin August 07, 2006
 
2.
v. Often used in MMORPG's to indicate the action of being defeated by a single attack.
This noob tried to gank me, so I turned around and one-shotted him!!
by FeudalWarlord January 14, 2006