Top Definition
When a Directioner claims to want the D of one of the members of 1D, mainly used to insult directioners. (Not to be confused with One Direction Infection )
Bob: Oh my god Cathy, looks like you have a bad case of the One Direction Yeast Infection
Cathy: Shut up!
by Alice Damsmann February 15, 2014
6 Words related to One Direction Yeast Infection

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