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1.
One direction Infection is only the best illness ever
Symptoms -
Excess Drooling, fainting and a major love for one direction; Harry styles, Liam Payne, Louis Tomlinson, Zayn Malik, Niall Horan.
Girl: Do you have bieber fever?
Shannon Fowler: No, i have one direction infection!
Girl: omg, me too!
Shannon Fowler: I love them!
by Shannonloves1D January 23, 2011
 
2.
An obsession with the boy band One Direction (aka the parasitic offspring of Justin Bieber and Miley Cyrus). Symptoms include sexual frustrations, a massive drop in IQ, and the inability to think, speek or type coherently. If your daughter or someone close to you acquires this illness, the only form of treatment is to tie this person to a chair, throw this chair into a large vat of salt and holy water, and play Metallica nonstop an at maximum volume through headphones duct-taped to their heads. If that doesn't work, murder is the only solution.
"Omqqq, I luv one DirEction! I think I have a one direction iNfection! <3 Harry styles and that Nialler, hot damn! ;)"

"AAAHHH! KILL IT!!! KILL IT WITH FIRE!!'"
by EdanP February 04, 2013
 
3.
A horrible diease that cuases the victim to go deaf and eventually dead. It infects a person due to the fact that he/she (Mainly Females) have listened to one direction music.
Infected Woman: OMG! I LOVE THIS ONE DIRECTION MUSIC! LIKE OMG!!!
Man: HOLY SH*T MY GIRLFREIND HAS THE ONE DIRECTION INFECTION! -The man runs far away-
by Surviorduide December 02, 2013