Top Definition
When you get on the school bus, not having to go to the bathroom, and the minute the doors close and it starts to go, you suddenly have to go to the bathroom REALLY BAD!!!!!
John: Dude, I suddenly have to go pee really bad! But the bus just started to go, so I gotta wait another 30 min before i get home!
Smee: Haha, sounds like you have On the Bus Syndrome
by the Moose of Man September 24, 2011
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