Apart from 'One True Paring',
OTP is New Zealand slang for 'On the piss '.

'Piss' can be slang for alcohol, so On the Piss means to be drinking alcohol (usually a lot) or used when someone is talking about drinking alcohol in the future.
(Facebook status):
Getting OTP this weekend!
or
*Jacky* and I are OTP! Great party!
by newzealanderyeah December 30, 2011
One True Pairing. The ship that you ship the hardest.
Harry Potter and Ginny Weasley are my OTP.
by stefanvh October 24, 2014
Otp means one true pairing, but let's be honest. We all have more than one! When your otp does something even remotely cute, your heart practically poops it's pants. You may also throw yourself off of a building and/or sell your soul to satan so you won't feel any more pain.
Person One: Destiel was soooo cute last night!
Person Two: I know they're my OTP! I almost threw myself out the window but instead I just ate my feelings again.
by athena_cabin_101 January 20, 2015
1. One true pairing meaning a combo of two fandoms or celebrities or characters you like.

2. Orgasm tipping point which is the last 1% of the orgasm where your body totally takes over from your mind and takes you (and sometimes your lover) for a whopping ride.
1. Man... danisnotonfire and amazingphil are my otp

2. My body just gave out after my otp
by Why is life so hard January 28, 2013
One True Pairing. Meaning the your favorite combination of characters in a fandom.
Harry and Hermione are /so/ OTP.
by erica January 29, 2004
When you chose two people in a fandom to be romantically paired, no matter what gender or sexuality or age or state the characters are. Many people have multiple OTP's.
"Hey, who do you ship in Attack On Titan?"
I ship JeanMarco and EreRi. Those are like my OTP's!
by just_look_at_all_the_otaku_ October 25, 2014
One true parring. Usually used to describe your favourite couple or ship.
Percabeth is my OTP
by PERCABETHISMYOTP72 October 24, 2015
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