The process of destroying a Facebook message thread or a message board thread by posting wildly inappropriate images and videos, preferably of deformed and/or mutilated genitalia, to scare outsiders away.

Coined by Kojo Manu of Baltimore
Roommate #1: Hey, check it out. my boyfriend left his Facebook up!

Roommate #2: Lolz. Mess with it

#1: Yeah I'm going to post in his messages: "Hi guys Johnny left his fb up, it's his gf"

#2: What did they say
(pause)

#1: What does "nuke the thread" mean?
(pause)
#1: Oh GOD! They keep posting pictures of micro-penises!

#2: Close the page!
by gurrilla55 September 21, 2010

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