The process of destroying a Facebook message thread or a message board thread by posting wildly inappropriate images and videos, preferably of deformed and/or mutilated genitalia, to scare outsiders away.
Coined by Kojo Manu of Baltimore
Roommate #1: Hey, check it out. my boyfriend left his Facebook up!
Roommate #2: Lolz. Mess with it
#1: Yeah I'm going to post in his messages: "Hi guys Johnny left his fb up, it's his gf"
#2: What did they say
#1: What does "nuke the thread" mean?
#1: Oh GOD! They keep posting pictures of micro-penises!