A condition marked by blisters, which come after a long session of playing a video game. So named because the NES Controllers caused this condition frequently.
I beat Renegade, and all I have to show for it is a bad case of Nintendo thumb.
by Wadatah May 21, 2005
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The numbness of the thumbs and index fingers commonly occurring after hours of game console use.
"Those fucking Covenant sonofabitches are giving me nintendo thumb!"
by Keith November 30, 2003
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