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1.
1. The act of taking a large pinch of chewing tobacco and inserting into a partner's anus, and "packing" the chew into a partner's anal cavity.*

2. May also be used for personal pleasure by pushing the chew into one's anus with their thumb.*

*(Each act will result in the recipient of the chew in the anus to experience a form of extreme euphoria)
1. I gave a bitch a muzzleloader the other night, only to have her puke all over my sheets.

2. Whenever my masturbation sessions get boring, I like to give myself a muzzleloader with cherry Skoal.
by Deezzz Nutzzz March 02, 2009
 
2.
The vile (or pleasant) act of defecating into your mate's mouth and proceeding to force the excrement down his/her throat with your penis. Your mate's mouth acts as the muzzle, the exrement acts as the bullet/gunpowder, and your penis acts as the ramrod. Hopefully your mate will projectile vomit immediately after being muzzle-loaded, so as to replicate the firing of the loaded firearm. If you wish to take it a step further, you can hire a Civil War Commander reenactor to shout out commands during the process such as "Prime!" "Draw Ramrods!" "Ram down the cartridge!" and "Fire!"
Dan: Bro, I hired a Civil War Commander reenactor to shout out the proper commands as I performed the muzzle-loader on your mother last Thursday.

Mike: Did she projectile vomit?

Dan: Hell yeah!

Mike: Nice!
by Mike Dumas May 20, 2008
 
3.
When you are doing a chick in the ass, right after you pull out her anus is still expanded and you insert your dip into her anus then stick your dick in and continue. Hence you are loading the muzzle.
I was bored so i muzzle loaded that bitch!

My pledge name is Muzzle Loader
by Coach Taylor September 16, 2007
 
4.
The act of using your erect penis to stuff your friends nuts into a bitch's mouth.
"Me and my bro gave some bitch the muzzle loader last night! She was gagging on his balls AND my dick!"
by G00N3Z January 14, 2012
 
5.
The act of having vaginal/anal sex with a partner and using your semi-erect penis (ram rod) to shove your testicles (ammunition) in the desired orpheus (muzzle) like that of a muzzle loading rifle. (Once your testicles are in the desired hole, you may also put your penis in the unoccupied hole if you so wish.)
"Bro! Last night I totally gave this haggard chick the Muzzle Loader in my car! I wasn't shooting blanks either!
by DFaseen September 05, 2011
 
6.
A muzzle loader is when you are doing a chick from behind and then pull out and put your dip in her pussy and keep going.
Jameel: I did the muzzle loader to a chick yesterday.

Brent: You fucker. you wasted dip on that cunt.
by jzee August 20, 2007
 
7.
During gay sex, one man takes a shit in the other mans anus. (see alabama hot pocket) The man who took a shit then fucks the other man in the anus. The man who was fucked in the anus then expels the packed-in feces out of his anus, creating the effect of a muzzle loader rifle.
Matt performed the muzzle loader on his gay partner.
by t nigs May 14, 2007