Top Definition
Akin to that of a "Phone Five" whereby when talking on a mobile phone you yell "PHONE FIVE!" and each caller slaps their phone to simulate a 'High Five' without being near one another.

A mouse five takes place on computer instant messaging after something of great excitement or accomplishment have been achieved.

Both Parties raise their Mouse and slap it!
Adam: "I just got someone to babysit tonight, so we can play poker!"

Jon: "Mouse Five!"

*Slap Mouse*
by JonnyBGoodwin September 30, 2010

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