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1.
Monosyllabic (adj): Lame. Used to describe anything not awesome.
Jerry: Man, this pie isn't all that great.
Bob: Yeah, it's totally monosyllabic.

Phil: This movie is nothing like the commercial!
Micky: It's really monosyllabic.
by Albertus Farbrengin November 27, 2010
 
2.
Composed of one syllable words. Going against the pronounciation of the word itself.
Monosyllabic sentence: This is a look at these kinds of words.
by Zak May 03, 2003
 
3.
pertaining to words of one syllable.
The conversation was pretty much monosyllabic.
by mek November 24, 2002